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DIYBio News Round-Up

May 13, 2014

Cat Ferguson

Cat Ferguson

Cat Ferguson

Hey there biohackers! Mac and Jason have asked me to dust this blog off a little and take it for a spin. I’ll be joining you once a week, right here, to recap what the DIYBio community has been chewing on lately. Under every headline, you’ll find a link to the Google Group discussion of the topic. I’m also planning on regularly digging deeper into cool projects and events, so be sure to get it touch via email or Twitter and let me know what you’re up to.

On to the news – this one’s longer than usual, since I have some catching up to do!

Hello world: new DIYBio spaces

The Wet Lab opens in San Diego

Discussion

The Wet Lab is currently focusing on “developing a greener future through the benefits of plants and algae,” but members expect to expand their projects soon. They’ve made their home at the San Diego Fab Lab, and they’ve got fifty people on their Meetup after five months, which seems like a pretty good start to me. They meet Wednesdays at 6:30, and optional membership dues are a bargain at $5 a month. They’re setting up their own wetlab soon. It’s organized by Cameron Clarke, a Biocurious alumn, and they’re building bioreactors for algae production, so check it out if you’re in the neighborhood.

Open Discover Institute launches DIYBio Store 

Discussion

The Open Discover Institute (ODIN), a project by NASA scientist Josiah Zayner, has started taking pre-orders for hardware and wetware at reasonable prices. ODIN is happy to ship to residential addresses (as Zayner put it on the DIYBio Google Group, “Of course I will ship to residential addresses that is the whole point!”). A basic lab starter kit will run you about $750, and 50 uL of a DNA ladder is listed for $11. Gift certificates are available for that special hacker in your life.

Zayner expects to start shipping in June. Next up for the ODIN store: refurbished PCR machines and centrifuges, though no word on timing for those.

Upcoming international events

Bring your tents to Finland for bio-nerd camp 

Discussion

Pixelache Helsikis is a Finnish group dedicated to fighting “an ‘ache’ to re-engage with non-digital interfaces and systems.” They’re running a camp from June 6-8 on Variosaari Island, off Helsinki. That’s a literal camp, involving tents and everything; the island is a nature preserve you get to via ferry. The Finnish Society of Bioart will be holding a workshop the whole weekend with a focus on “Bio-Commons,” bio resources freely available to the public.

Topics under discussion include legal concerns surrounding access to both natural and man-made resources; various approaches to licensing biotechnology; and ethical and societal issues relating to DIYBio. Keynote speaker is Markus Schmidt, a scientist-turned-communicator who writes widely about ethical and policy issues related to synthetic biology.

You can help plan the conference here, or submit relevant comments and artwork to  Rüdiger Trojok.

Barcelona Fab Lab Conference 

Discussion

The 10th annual International Fab Lab Conference is coming up July 2-8 in the capital of Catalonia. A week of workshops, conferences, exhibitions, and a symposium in one of the prettiest cities in the world. The main event, the Fab Festival, is from July 5-6. They’re expecting 10,000 people and hundreds of activities.

There’s also a contest for open-source maker projects that closes May 31, so if you’ve got a cool digital fabrication project, now’s the time to get it together. Everything you submit will be up for public grabs, and finalists will have their projects displayed at FAB10. They’re looking for community problem solving, sustainability, and aesthetics – plus a People’s Choice Award with a special prize.

A certain writer is dying to go to lovely España, so if you’re interested in sponsoring a DIYBio press trip to FAB10, shoot me an email.

Hackers in the Himalayas 

Discussion

On the weekend of October 24, in Dharamshala, India, a group of hackers from across the world is getting together for hillhacks, a weekend-long conference, Makerfaire, and workshop series. The planners hail from San Francisco, Tibet, and everywhere in between.

Schedule and events are still being fleshed out, so feel free to hit the mailing list, join the conference calls, and lend a hand. More info here.

Classes and fellowships

Advanced Manufacturing Research Institute announces summer 2014 fellowships 

Discussion

The second annual AMRI fellowship will be kicking off on June 15 and running through August 31. Held at Rice University in Houston, TX, fellows will work with Dr. Jordan Miller developing open-source biology tools.

Applicants should have some experience with open-source platforms tech, like Arduino or Raspberry Pi. But don’t let age hold you back – the only requirement is a high school degree by the time the program starts.

Fellows get a $5,000, and will work on one of four projects: 3D printed prosthetic hands and fingers; selective laser sintering; using organic light emitting diode screens as a light source for 3D printing living tissues; and open source ink jet printing of bacteria. Applications due May 15 at midnight. Click here for more information.

Coursera on data analysis tools 

Discussion

Any aspiring bio-statisticians should head over to Coursera for a free crash-course in data science tools, including markdown, GitHub, R, and RStudio. Students will also learn the concepts behind turning data into useful information. No prior experience required, but you might want to know some programming basics.

Next class starts June 2. Runs for four weeks, three to four hours a week.

News from around the web

Electric current may be the key to lucid dreams

Discussion

It’s not exactly DIYBio, but you guys have been chatting about it and it’s all over the internet. So if you’re interested in applying current to your scalp and controlling your dreams, check out the Verge article and the Nature Neuroscience paper. For a clue what the discussion link above holds, it involves an electrified spaghetti strainer, burnt hair, and a possible dream helmet run off Arduino.

Scripps researchers add two new letters to the genetic alphabet 

Discussion

This one’s a little crazy. Floyd Romesberg and Denis Malyshev have synthesized a third base pair, which they’re calling X and Y, and gotten E. coli to take it up and replicate it by sticking it in a plasmid and modifying the bacteria to take it up. Apparently people have been trying to do this for a while now? Anyway, the bacteria can’t make proteins with the unnatural base pairs (although theoretically something like this could bump possible amino acids from 20 up to 172). So it’s an interesting finding, but it remains to be seen how useful it actually is.

Here’s the Nature paper and a pretty great, in-depth news article from the San Diego Union-Tribune.

A reminder about Ask a Biosafety Expert

 22 questions & counting!

How do I dispose of BSL-1 sharps? Should I dump E. coli down the drain? If I keep fecal samples in my bedroom, how bad is that on a scale of 1-10? Pose these and any other questions you might have to ask biosafety experts, right here. Check out the existing answers, and stay safe out there!

 

DIY+iGEM

November 6, 2013

100ideas

iGEM + DIYBIO logos

The International Genetically Engineered Machines Competition (iGEM) is opening to DIY teams next year. It’s grown from a small experiment with 5 teams in 2004 to the largest community and conference of synthetic biologists in the world (with over 200 teams competing in 2013). I’m on the organizing committee for the new track – the “Community Labs” track – and I’m terrifically excited about the opportunity the iGEM competition provides for growing DIYbio.

I was asked to make the announcement at the recent iGEM World Jamboree, and below you can read a rough transcript of what I said. But if you just want to details, here they are:

DIY teams:

  • get the physical biobrick parts kit (DNA of over 1000 standard biological parts)
  • pay the same fees (~$3000 + $450 / person)
  • need two “PI” leaders (anyone can be one)
  • need a legally-recognized company to host the team (start your own, or ask a public lab to host your team; the two PIs need to be part of the team company)
  • compete amongst other teams in the DIY track to win the track prize
  • compete amongst all the teams for other prizes, including the GRAND PRIZE
  • can have members of any age
  • can be any size

Running an iGEM project is a big job, there’s no doubt. But if you’re up to it, you can use the competition as a powerful organizing tool for recruiting talented scientists, engineers, artists, and biohackers to work together and as a motivating force to solicit funds from many different local and national donors.

If you’re interested in spending six months building and designing your own biological system with synthetic biology, think about starting or joining an iGEM team in 2014.

I’m planning on starting a San Francisco team, and I’m going to recruit from the local biohacker scene, as well as from the local biotechs, big internet companies, and research labs. I see iGEM as a beautiful way to bring together really smart people to figure out and do DIY synthetic biology.

For more info, look on the diybio@googlegroups.com list for iGEM threads or leave comments below. You can also email diy@igem.org if you have specific comments or questions for the organizers.

Good luck!
Mac


(I gave shortened version of this talk (7 min in) at the iGEM 2013 Jamboree, excited and out of breath after sprinting over from the middle of a judging meeting. Not the pomp and circumstance I was hoping for – but it is more fitting for DIY I think.)

Hi everyone. First, I want to applaud all your amazing work engineering and building biological systems here in iGEM. It’s simply amazing. So. I’m Mac Cowell and terrifically excited to announce a new iGEM track – the iGEM Community Labs track. But before I give you the details, I’d like to just talk for a moment about how iGEM and DIYbio relate from my perspective.

iGEM is an engine for innovation, like the scientific academy and the free market. But in addition to the accolades of scientific publishing and the economic rewards of the free markets, the real motive force that energizes synthetic biology innovation in iGEM is powered by a simple desire by the participants to “push the technology” as far as possible – and to HAVE FUN. This is an intrinsic and separate motivation but just as a valid and important as a wish to advance science or make millions.

Innovating for the sake of innovation itself is an incredibly powerful force, and it’s what excites me – and you – about the opportunity iGEM offers to “push the envelope” of biological technology.

The worldwide community of “amateur biologists”, biohackers, citizen scientists, or otherwise “non-institutional scientists” are motivated in the same way. They want to push the envelope of biological technology. They want to, in general, increase the power of an individual to understand biological systems – “to understand things” – and to prototype biological designs – *to build things*. They ask why the tools we use as biological engineers – protocols and equipment and organisms and genes – are the way they are, and perhaps not simpler, less expensive, or just easier.

Like iGEM, the worldwide biohacker community thinks outside the box and innovates for the sake of innovation.

I was once an iGEM participant – in 2005. Over the following years, the I was continually amazed by the innovation at the edges of synthetic biology that iGEM stimulated. And most surprising of all, it was being done by you – undergraduates. Not teams of PhDs working for academic fame. Not companies motivated by profits. By you iGEM youngsters, driven by the simple obsession of inventing something *new*.

So in 2008, inspired by the community of iGEM biohackers – those kids inventing for invention’s sake, pushing the boundaries of what’s possible with synthetic biology – I coined a phrase with my friend Jason Bobe in an attempt to name the community with similar ideals outside of iGEM. We named it “diybio”. That name was a pebble at the top of a mountain. And over the last 5 years, it seems to have caused a landslide. But the two of us just gave it it’s first little push.

But despite their fundamental alignment, the diybio & iGEM communities have not formally intersected – until now.

In 2014, DIY teams operating their own labs are invited to participate in iGEM. The fees will be the same as for other teams – roughly $3000 to register and $450 per participant going to the Jamboree. DIY teams will receive the part distribution and will compete with other DIY teams in the track, as well as being eligible for awards from the other iGEM tracks as well as the grand prize. In other words, a DIY team, like the teams in the other tracks, could be the ultimate winner of the competition. DIY teams are required to have two leaders – or “PIs” – who do not have to be accredited scientists, but who do need to be listed as managers or leaders of the company that runs the teams lab space.

If a team wants to form a new lab, that’s fine – they’ll just need to create an LLC or C-corp or other legal entity as an umbrella for their activities. Or they can ask members of an existing organization to act as the PIs of the team. Importantly, these PIs and the associated legal entity are what become responsible for the activities and behavior of the team – not the iGEM organization.

iGEM requires a large investment in time and money to participate, but its format as annual competition actually facilitates fundraising, recruitment, and general motivation to do something BIG. It provides a compelling vehicle to organize a team, a lab, and get a project done on time. Having observed the competition grow from 13 teams in 2005 to over 200 teams in 2013, I’ve noticed time after time how much easier it is for teams to raise money when they tell donors “we need this money to win! support us and the local community,” instead of “we need this money to do our science project – please support us and science!”.

In my opinion, the new DIY track could stimulate many new community labs and teams to form with great benefits to the diybio community.

Anyone can start a team, and for you, I have two critical suggestions. As the leader of the team, you’ll have two main jobs in the beginning, just like a CEO: 1) recruiting awesome teammates, and 2) raising money to support the team.

Start with recruitment first. Put together a talk or presentation about what iGEM is and why you’re excited about participating, then go to your local communities that might have awesome people interested in helping, and get them excited! Go to local biotech companies, research labs, retiree communities, schools, museums, hackathons, lightning talks, science nights, and any other venue you think might be a filter for smart, capable, motivated people interested in biohacking. You can use iGEM to build an amazing local team of talented scientists and engineers.

Once the team starts to come together, do the same roadshow at local businesses, asking for sponsorship. Tell them you’ll put their logo all over your tshirts and website etc. Try to get some grants from the city. Ask for $1000 from the awesomefoundation.org.

DIY iGEM teams in 2014 are a huge opportunity to build the strength and reach of DIYbio everywhere. I encourage you all to consider starting teams and using iGEM as a focal point for getting great people and real money involved in DIYbio.

More details about participating will be available at iGEM.org in 2014. In the meantime, please direct any questions or comments to diy@igem.org.

Get excited!
Mac Cowell

Funding Models for DIY biologists

December 14, 2012

Jason Bobe

Over at Nature’s SpotOn, Rayna Stamboliyska asks the question: “How do we make DIYBio sustainable?”

Check out her review of funding strategies in the DIYbio community to-date, including:

  • membership fees (e.g. Biocurious)
  • fee for service (e.g. workshops at Genspace)
  • grant funding (e.g. MadLab UK)
  • crowdfunding (e.g. Open PCR)
  • commercialization (e.g. Amplino)

Thanks Rayna!